||Preface. After publication of the presented hypothesis some predictions were verified independently by other authors: (1) Monro-Kellie "four compartments" doctrine, (2) relation between CSF formation and CSF removal in physiological phase as presented with illustrative curves, (3) hypovolemia during intracranial hypotension syndrome, (4) increased CSF proteins in decreased CSF flow and (5) influence of neuro-vegetative system on CSF pressure. The predictions not yet verified: (1) turning points B-low and B-high that represent physiological borders, (2) pathophysiological self-sustaining phases of low and high CSF pressure with corresponding minimal or maximal CSF volume (maximal dural sac collapse or distension) and no CSF transport, (3) compensated and de-compensated conditions. None of the predictions were disproved yet. The purpose of this presentation on the INTERNET is to promote further discussions about unverified predictions and to encourage clinical research and experimenting in this direction. Summary. Physiological and pathophysiological processes in the intracraniovertebral space are specific because of its rigid and constant volume (Monro-Kellie doctrine). The hypothesis presents how the homeostasis of the intracraniovertebral compartments' volumes, cerebrospinal fluid (CSF) flow and CSF pressure is physically regulated. The hypothesis takes into account the quantitative and qualitative relations regulating CSF formation and CSF removal on which the homeostasis is based.